필러 입자를 함유한 4-META/MMA-TBB 레진의 항균 활성
Antimicrobial activity of modified 4-META/MMA-TBB resin filled with pre-polymerized filler particles
김민정, 김현진,
소속 상세정보
김민정 ( Kim Min-Jeong ) - 경북대학교 대학원 의용생체공학과
김현진 ( Kim Hyun-Jin ) - 경북대학교 대학원 치의과학과
KMID : 1035320140410040319
Abstract
In this study, to evaluation the chlorhexidine (CHX) release from the modified 4-META/MMA-TBB (4-META) resin filled with pre-polymerized filler containing human serum albumin (HSA) nanoparticles. The 4-META resin and modified 4-META resin specimens containing the CHX-loaded HSA nanoparticles were prepared as follows manufacturer. The morphology of the resin containing nanoparticles were observed using scanning electron microscopy (SEM) and in vitro release profile of CHX from the resin was measured by placing the samples in phosphate-buffered saline (PBS, pH 7.4) at 37˚C for up to 30 days. The SEM image of the resin clearly shows that the CHX-loaded HSA nanoparticles were homogeneously dispersed and well-incorporated in the two different resin matrix. Moreover, CHX was successfully released from the two different resin matrix for a long period of time (up to 30 days incubation time). However, in comparison with the 4-META resin containing CHX-loaded HSA nanoparticles, the release profile of the modified 4-META resin containing CHX-loaded HSA nanoparticles showed a lower amount of CHX released over the study period. The flexural strength and tensile bond strength remains unchanged by incorporation of CHX-loaded HSA nanoparticles and CHX powder in two different 4-META resin (p > 0.05).
키워드
4-META/MMA-TBB resin; antimicrobial; chlorhexidine; pre-polymerized filler; tri-n-butylborane
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